Screening of Donor and Candidate Prior to Solid Organ Transplantation - Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

Abstract

This updated section of the guideline from the Infectious Diseases Community of Practice of the American Society of Transplantation reviews the screening of donor and candidate prior to solid organ transplantation. Screening of donor and candidate is vital for optimizing post-transplant outcomes. Risk assessment based on detailed history and appropriate diagnostic evaluation is vital. Serologic screening for certain viral infections is important and aids in immunization counseling and risk mitigation of recipients. In addition to serology, nucleic acid testing for Hepatitis B, Hepatitis C and Human Immunodeficiency Virus has been required for deceased and living donors. Certain endemic exposure may warrant additional evaluation beyond recommended standard testing. Diagnosed infection in the donor or recipient warrants treatment as well as additional testing and/or prophylaxis to mitigate post-transplant risk. Certain infections in the immediate pre-transplant period may warrant delay of transplantation. 

Authors

Malinis M1, Boucher HW2; AST Infectious Diseases Community of Practice.

 

Clin Transplant. 2019 Mar 21:e13548. doi: 10.1111/ctr.13548. [Epub ahead of print]

Author Information

  1. Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, 333 Cedar St, P.O. Box 208022, 06520-8022.

  2. Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, 800 Washington Street, Box 238, 02111.

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